WHO has two main indicator , when it dealt with influenza virus outbreak.
The first one is Pandemic Alert Level,which defines the stages of a pandemic, outlines WHO's role and makes recommendations for national measures before and during a pandemic.The chart is given below
| WHO Pandemic Influenza Phases (2009) |
| Phase |
Description |
| Phase 1 |
No animal influenza virus circulating among animals have been reported to cause infection in humans. |
| Phase 2 |
An animal influenza virus circulating in domesticated or wild animals is known to have caused infection in humans and is therefore considered a specific potential pandemic threat. |
| Phase 3 |
An animal or human-animal influenza reassortant virus has caused sporadic cases or small clusters of disease in people, but has not resulted in human-to-human transmission sufficient to sustain community-level outbreaks. |
| Phase 4 |
Human to human transmission of an animal or human-animal influenza reassortant virus able to sustain community-level outbreaks has been verified. |
| Phase 5 |
Human-to-human spread of the virus in two or more countries in one WHO region. |
| Phase 6 |
In addition to the criteria defined in Phase 5, the same virus spreads from human-to-human in at least one other country in another WHO region. |
| Post peak period |
Levels of pandemic influenza in most countries with adequate surveillance have dropped below peak levels. |
| Post pandemic period |
Levels of influenza activity have returned to the levels seen for seasonal influenza in most countries with adequate surveillance. |
The second is PANDEMIC SEVERITY INDEX The index focuses less on how likely a disease will spread worldwide-that is, become a pandemic-and more upon how severe the epidemic actually is.The main criterion used to measure pandemic severity will be case-fatality ratio (CFR), the percentage of deaths out of the total reported cases of the disease.The table is given below
| Category |
CFR |
| 1 |
less than 0.1% |
| 2 |
0.1% to 0.5% |
| 3 |
0.5% to 1% |
| 4 |
1% to 2% |
| 5 |
2% or higher |
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